Yes, I remember that major depressive disorder is a very serious mental illness. It is said that it originates from a combination of genetic and environmental factors, and stress is the main environmental risk factor. " Lin Ge was also skeptical. He did not believe in Dr. Lance Payne's views and treatment at all.
"There is still a principle." Although Zheng Ren did not believe that fecal transplantation could treat major depression, he still told the truth. "More and more evidence shows that the microbiome is an environmental factor that can shape the brain through the microbiome, gut, and brain axis. Mice with changes in the microbiome usually show depression-related behavior."
"It is said that it has something to do with the NLRP3 gene," Su Yun added.
"What N?" Lin Ge was stunned.
"Uh …" Zheng Ren found it difficult to explain clearly. He thought for a moment and said, "To put it simply, it's to make a capsule out of the feces of mice that have knocked out the NLRP3 gene … a gene related to depression, and give it to the patient."
"…"
Lin Ge and Department Chief Kong were stunned.
Although they had been through hundreds of battles, the thought of yellow dragon soup, mouse feces … Just thinking about it made them feel disgusted. Now, they had to take the feces of mice orally. Could this really treat diseases?
"Department Chief Lin, what's with that expression?" Su Yun was overjoyed. He pretended to look at Lin Ge seriously. "Eating mouse feces has been around since ancient times."
"I know that there is a kind of snack that children eat called mouse feces. My friends in Jinling are still looking for it all over the world during the New Year. Unfortunately, they are selling less and less. "
"What you're talking about is a snack made of tangerine peel, plums, white sugar, and hawthorn." Su Yun chuckled. "You exposed your age with just one sentence. What era is this? Who still eats mouse feces?"
"Memories, memories."
"There is mouse feces in traditional Chinese medicine, do you know that?" Su Yun mischievously brought the topic back.
"Five spirit fat, the feces of compound toothed flying squirrel," Zheng Ren said. "It mainly treats the cold in the heart and abdomen, children's five viscera, ward off epidemics, intestinal wind, and meridians."
"It's not professional for you to say that …"
"It's good that you know what I mean. Why do you have to be so professional?" Zheng Ren said. "Using fecal transplantation to treat major depression is still in the animal experimental stage, and I'm not optimistic about this kind of animal experiment."
"Just because you can't tell if the mouse is really depressed? In fact, it's still possible to judge through activities, communication, and play. "Su Yun smiled and continued to talk about depression.
"If it's to treat Clostridium difficile infection, we can try fecal transplantation, but it's very risky," Zheng Ren said. "But …"
"Don't talk nonsense. They found an American expert to treat it. Do you believe that if you deny it so openly, Director Mao's people will directly kick you out?" Su Yun blew a breath, and the black hair on his forehead fluttered in the wind.
"I don't think so."
"Why not? I heard that Director Mao is in the middle of his illness. No matter who he sees, he will shake hands and apologize. His memory is also very good, even a small detail can be said for a long time. "Su Yun said.
"Oh? They felt that their lives were worthless, and they felt extreme guilt, remorse, helplessness, despair, and self-abandonment. These points are quite consistent with major depressive disorder, "Zheng Ren said." If that's the case, there's no good way. "
When Lin Ge heard Zheng Ren say this, he lowered his head and sighed.
"Tsk, are you talking about the DSM-IV-TR diagnostic criteria or the ICD-10 diagnostic criteria?"
"Neither." Zheng Ren did not want to argue with Su Yun today. He said directly, "I still agree with Chief Mei's statement. It's normal medication treatment. Fecal transplantation, whether it's through the intestine or oral capsules, may cause more and bigger problems. "
"Okay, Chief Zheng, I will reflect your opinion to the hospital," Lin Ge said cautiously.
"There have been many new research findings regarding fecal transplantation recently. For example, in a study in the journal Cell in August 2019, Erick Riquelme and Florencia from the Anderson Cancer Center in the United States
Riquelme和Florencia
McAllister's research found that a small number of long-term pancreatic cancer patients had significantly more diverse microbes in the tumor. "
"Fecal transplantation can treat cancer?" Lin Ge was surprised.
"It's just a discovery. Whether it works or not, we still need a long time of research," Zheng Ren said. "It might also be a wrong direction. Fecal transplantation is a good thing, but I don't think it should be used in the clinical stage. "
"Okay."
Lin Ge nodded. Then, he stood up and said, "Chief Zheng, I'll report to the hospital."
"Chief Lin, it was said that after Chief Mao and her husband confessed, her husband was angry for an hour, then slammed the door and left. Is there such a thing?" Su Yun continued to gossip.
Lin Ge smiled bitterly.
"Why are you asking so much? It has nothing to do with diagnosis or treatment," Zheng Ren said.
Hearing Zheng Ren's words, Lin Ge smiled apologetically and turned to leave.
Zheng Ren then said a few words to Chief Kong and left the office.
"Boss, do you really think fecal transplantation is unreliable?" Su Yun asked.
"It's not unreliable, but it takes a long time of research. The treatment for Clostridium difficile has already been used in clinical practice, but the mortality rate is very high. "
"If you don't use it, the mortality rate is close to 100%," Su Yun retorted directly.
"Who knows? The method of internal medicine has nothing to do with us." Zheng Ren did not want to think about these things. It was enough to be a good surgeon.
"Boss, the discipline of interventional surgery belongs to the imaging profession. It's a clinical auxiliary discipline." Su Yun's mouth was too big. He misinterpreted the meaning and directly attacked Zheng Ren's weakness.
Zheng Ren could not be bothered with this guy. He returned to the office and continued reading.
This time, he was looking for information about fecal transplantation.
If fecal transplantation wanted to become a routine clinical treatment, it would take at least twenty to thirty years.
Zheng Ren was just looking at it for novelty. He did not want to study it from beginning to end. Even the Eye of Truth skill was already on cooldown, so Zheng Ren did not want to use it.
Who knew how big the scope behind a research was? If he used it casually, it was very likely that his energy would be drained and he would faint.
Zheng Ren learned from his mistakes. The Eye of Truth could not be used casually. The gastric fundus and left gastric artery embolization surgery could be seen at a glance. After all, it was simple.
As for fecal transplantation …
As a new treatment method, it involved a wide range of categories. It seemed to be able to be found in treating bacterial imbalance, depression, cancer, and diabetes.
There was a lot of information. The more Zheng Ren read, the more he gave up on the idea of using the Eye of Truth to find out the truth. It was so majestic. If he looked at it, he would probably not faint but really die.
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