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Acetaminophen was known as paracetamol a long time ago. As the name implied, it could relieve fever and analgesia.
The drug reduced the synthesis and release of prostaglandin PGE1 by inhibiting prostaglandin synthase in the hypothalamus' thermoregulatory center, causing peripheral blood vessels to dilate and sweat to achieve the effect of relieving fever. Its relieving fever effect was similar to aspirin.
The analgesic effect was not strong. It was only effective for mild to moderate pain.
Sulfhydryl donor
N-acetylcysteine was a special drug for acetaminophen poisoning.
Zheng Ren saw this in the doctor's orders and knew that the ICU had already used the right medicine, so he did not say anything unnecessary.
The power of the 912's serious illness was quite strong. Other than the strange situation of the urine discoloration caused by propofol, Zheng Ren felt that he did not need to interfere too much.
In the face of a patient with liver failure caused by acetaminophen poisoning, he needed the strength of a group to treat him.
This was a clear diagnosis. An experienced doctor would know what disease it was at a glance.
However, treatment was very difficult, even more difficult.
"Why did you eat so many Yinqiao tablets?" Su Yun looked at the medical record and frowned. "Do you really think that Yinqiao tablets are Chinese medicine?"
Zheng Ren and Professor Yang both sighed. No one said anything.
The description of the Yinqiao tablets said that they could expel wind and relieve exterior symptoms, clear away heat and detoxify. It was used for fever, headache, cough, dry mouth, and sore throat caused by wind-heat cold.
The standard Chinese medicine vocabulary gave people the feeling that this was Chinese medicine.
When they had a cold, many people were willing to add a set of Yinqiao tablets to take orally. The effect was indeed not bad.
However, if one looked carefully at the instruction manual of the Yinqiao tablets, its ingredients were not that simple.
Honeysuckle, forsythia, bramble, fermented soybean, lophatherum, burdock, reed root, platycodon, etc., licorice, chlorphenamine maleate, acetaminophen, vitamin C, peppermint oil.
Chlorphenamine maleate, also known as chlorphenamine, was an antihistamine drug.
This drug component had an anti-allergic effect through the antagonism of the H1 receptor. It was mainly used for rhinitis, skin mucous membrane allergies, and to relieve crying, sneezing, runny nose, and other cold symptoms.
Next, it also contained acetaminophen, a drug component that would reduce symptoms if taken in small amounts and cause liver failure if taken in large amounts.
Each Yinqiao tablet contained more than 100 paracetaminophen.
Therefore, its effect was very good. After many twists and turns, it still returned to acetaminophen.
In addition, the other cold medicine also contained acetaminophen. Not only did this child named Chen Li take double the oral dosage, but he also took several drugs in combination.
The amount of acetaminophen consumed … was almost lethal.
Every drug had its effects. While benefiting the human body, there would also be hidden dangers.
If it was consumed in large quantities, not to mention medicine, even bananas would not be enough. Not to mention eating well, even drinking too much water was not allowed.
The word 'appropriate' was correct.
Zheng Ren looked at the medical record, his brows furrowed together like the straps of a sterile surgical gown.
'It's very difficult to save Chen Li,' Zheng Ren thought to himself.
During the process of reading the medical records, the directors and professors of the relevant departments in the hospital came one after another.
On the other hand, Vice President Yuan presided over the hospital consultation. Vice President Ye and Vice President Lin of the Medical Division attended the consultation.
Everyone's heart sank when they saw how seriously the hospital was treating this matter.
It was different from diseases like cancer. If a cancer patient was sick, life and death were up to fate. They just had to do their best.
However, in front of them was a young college student who had studied hard for more than ten years. He had not stepped into society yet and was about to leave the world for no reason.
Zheng Ren felt that the patient's family could not bear this point alone.
It was the greatest sorrow in the world for a white-haired person to send off a black-haired person. There was nothing more sorrowful than this.
The chief resident was the one who reported the patient's medical history in the ICU. He tried his best to report the patient's medical history in a concise manner. The doctors who came later had a basic understanding of the situation.
Acetaminophen poisoning, acute liver failure, peritoneal effusion, coagulation dysfunction, and more than ten diagnoses were clear.
The ICU had already started to replenish platelets and used artificial liver blood purification technology to treat the patient.
Artificial liver blood purification technology referred to plasma exchange and blood adsorption technology.
It adsorbed inflammatory substances or toxins dissolved in the blood onto solid substances with a rich surface area to remove inflammatory substances and toxins from the blood.
For this student named Chen Li, as long as the residual acetaminophen in the liver and blood was filtered out.
Artificial liver technology was specially used for blood detoxification.
It used the method of "blood exchange" to remove the toxins in the patient's plasma. In other words, the patient's plasma containing toxins was replaced with healthy plasma. Each time, about 50% of the plasma in the body was replaced.
However, this was a measure to mend the pen after the sheep had been lost. It did not allow the residual acetaminophen in the plasma to continue to damage the liver.
However, the artificial liver blood purification technology could not treat the damaged liver.
In 1986, Professor Li Lanjuan and her team from the First Hospital of Zhejiang University had carried out research and clinical application of this technology.
Until now, it was already a relatively mature technology. The critical care doctors of the 912 were proficient in it, so there was no problem in applying it.
After reporting the medical history, it was time for the directors and professors to speak.
In fact, there was not much that could be said or wanted to be said.
Illness. That was the illness.
This was the situation.
The patient's illness started quickly. Although he was sent to the hospital in time and dealt with properly, his condition was not optimistic.
This could be seen clearly on the faces of the ICU's chief resident, second-tier professors, and directors.
They had a judgment of the patient's condition and hoped that the patient would recover quickly after the symptomatic treatment.
However, from the time they took over until the treatment, they had their own judgment.
Their rich clinical experience was silently saying that all the treatment methods had been used, but the chances of the patient recovering were not high.
Not to mention the expensive treatment fees, the patient's daily expenses were at least 50,000 yuan. Only the severity of the condition …
Thinking of this, Zheng Ren had a headache.
"I suggest that we prepare for both sides and do organ transplant matching. If conservative treatment is not effective, we can perform a liver transplant," Professor Yang said. His words were very simple.
"What about Doctor Zheng?" Deputy Director Yuan looked at Zheng Ren and asked seriously.
"I agree with Professor Yang's point of view. I haven't seen the patient yet, but according to the calculation of the drug dose in the medical record, the patient has ingested too much acetaminophen. I think that the possibility of improving and correcting liver failure through various first aid methods is not high.
"I suggest that we prepare for a liver transplant … if we can find a liver source," Zheng Ren said firmly.
Zheng Ren said firmly.
In Zheng Ren's opinion, only a liver transplant could save this child.
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